It’s hard to focus when you start trying to learn about cancer, which is why you should begin with an overview. In less than half an hour it will give you a general idea of what this disease is and what you can do about it. After that, it will be much easier to understand what you find in books and other sources.
The author of this overview was treated in 1997. He based it on careful research, his own experience, and that of other patients.
The prostate, located directly below the bladder, is part of the male reproductive system. Most are the size of a walnut (½‑1 oz, 15‑30 cc), but they can be much larger.
C pubic bone
F pelvic-floor muscles
G seminal vesicle
There are no clear symptoms of early-stage prostate cancer. It is usually detected with two tests and confirmed with another.
DIGITAL RECTAL EXAM (DRE)
A doctor presses a finger against the wall of the rectum next to the prostate (at point D on the drawing). A slight hardness may indicate a tumor.
Prostate‑specific antigen (PSA) is part of the ejaculate. It is normal for some PSA to leak into the bloodstream, but more may escape if tumors develop.
The PSA level is measured with a blood test, but it is not a completely reliable indicator of cancer. A PSA of less than 1.0 does not necessarily mean there is no cancer present, and one as high as 10 may not mean there is.
Things that affect PSA levels include age, race, volume (size) of the prostate, urinary infections, and a non-cancerous type of tumor called benign prostatic hyperplasia (BPH). In addition, PSA levels can vary from day to day, so high PSAs should be tested again in a few weeks. Temporary rises may also be caused by such things as sexual stimulation, ejaculation, or long bike rides, so avoid them for at least two days before a PSA test.
The two types of biopsy are the transrectal (from inside the rectum) and the transperineal (from the area between the anus and the testicles). The first is the more common type. The patient should be given antibiotics before the biopsy to prevent infections, and a local anesthetic to reduce pain. A biopsy gun, guided by ultrasound, is used to inject a dozen or more very thin hollow needles into the prostate to collect samples of cells (cores).
There are several things you must know before you can decide on a form of treatment.
A pathologist examines the cells in the biopsy cores and rates them from one (normal) to five (very deformed). These are the Gleason grades. The sum of the two most common grades is the Gleason score (for example, 2 + 4 = 6).
The more-common grade (the primary) is listed first. If it is higher than the other (the secondary), or the score is more than six, the cancer is probably more aggressive. A score of less than six suggests that the tumors are growing slowly.
Most pathologists must deal with many kinds of cells, so your Gleason score may not be accurate. Get a second opinion of the biopsy slides from a pathologist who specializes in prostate cancer.
The clinical stage of the cancer is an estimate of the size of the tumors and how far the disease may have spread. The most common classification systems for prostate cancer stages are ABCD and TNM (Tumor, Node, Metastasis).
T1‑T2c or A1‑B2 are local or organ-confined. The tumor is still inside the prostate.
T3‑T4b or C1‑C2 are regional or extracapsular. The tumor is near or just outside the edge (capsule) of the prostate.
N1-M1c or D1‑D2 are metastatic or systemic. Cancer cells have reached the lymph nodes (N1‑N3 or D1) or other parts of the body (M1‑M1c or D2).
In the older I‑IV system, I is equal to A1, II to A2‑B2, III to C1‑C2, and IV to D1‑D2.
The stage is based on the DRE, PSA, Gleason score, how many biopsy cores contain cancer cells, the approximate sizes and locations of the tumors, and other tests.
Magnetic resonance imaging (MRI), ultrasound, and other tests can help estimate your stage more precisely and establish a baseline against which the progress of your treatment can be measured. They can also be used to create 3D computer images of your prostate to help plan the procedure.
Your clinical stage, Gleason score, age, test results, and other factors affect which of the procedures is likely to be the safest for you. Statistical tables called nomograms, based on the long-term results of the treatments of thousands of men, can be used to predict the likelihood of a successful procedure. There are, of course, other factors, such as how old you are and how much experience your specialist has, that can affect the outcome.
The National Comprehensive Cancer Network has estimated the risk of prostate cancer returning after treatment:
|AMOUNT OF RISK||LOW||MEDIUM||HIGH||VERY HIGH|
Don’t waste time and don’t rush into anything. Unless the cancer has begun to spread, it is more important to make a carefully thought out decision than a quick one.
IMPROVING YOUR CHANCES
Stress makes your life harder and may damage your immune system. Antidepressants, meditation, or other remedies may help. So do things that make you laugh.
Join a support group
It helps to know that you are not the only one with this problem, and to meet men who have dealt with it successfully. Group members and specialists who speak to the group may provide useful information about treatments and doctors. (But be wary of anyone who strongly recommends doing what he did. He may really be trying to convince himself that he did the right thing.)
Change your habits
Exercise and healthful eating habits can slow cancer growth. Tumors need calories, so avoid sugars, fats, and alcohol. Excess weight may make it harder to treat the prostate, make tumors more aggressive, make PSA levels seem lower, and increase the chances the cancer will return.
Eat less of all kinds of meat, especially red. Avoid charred or fried meat or fish. Cut back on eggs and dairy products. Eat fruit, especially citrus, and plants, especially tomatoes, garlic, onions, broccoli, and green, leafy vegetables. Nuts, beans, lentils, berries, whole grains, and olive oil are also good for you. Drink green, red, or white tea.
Be careful with vitamins and other supplements. Too many contain far more than the daily recommended amounts.
Talk to your family and friends Your cancer worries them too. Talking about it will help them deal with it and may help you work out your own feelings.
Cancer takes an emotional toll. You and some family members might benefit from it before and/or after treatment.
Do your homework
Learn as much as you can about prostate cancer and the treatments. Study your options carefully, and don’t let anyone pressure you into making a decision before you’ve learned enough.
Sources of information
Use as many as you can. E‑patient communities, patient diaries, and books are the most useful. Medical studies, TV news, newspapers, and websites are the least. See the link to Finding Reliable Medical Information at the end of this document.
HOW TO CHOOSE A PROCEDURE
There are more than half a dozen ways to treat prostate cancer. Don’t pick one before you’ve talked to several kinds of specialists.
Your choice of a specialist may be more important than your choice of a procedure. Avoid those who are inexperienced, aren’t up-to-date, or just don’t seem to care. If a doctor does not listen to you or answer your questions, find one who will.
Write down your questions before office visits. Take a recorder so you won’t have to write down everything. Bring someone to help you focus. Be there ahead of time.
Request copies of your biopsy report, prostate volume, every test that was done, and all other important health information. Make a list of the causes of death of family members, the medicines, herbs, and supplements you take, and any major health problems you have had. Records are too often lost, misplaced, or not available, so print or photocopy an extra set and bring it to every appointment.
Try to find out:
- Which procedures are likely to be appropriate for you.
- What the most likely side effects of each of them are.
- Who the best specialists for each type of procedure are.
- Where those specialists are located.
- If your insurer or managed-care organization will approve the procedure and the specialist you want.
- Which side effects worry me the most?
- Which procedure seems to make the most sense for me?
Find out as much as you can about prostate cancer and the procedure you choose. You should know what is happening (or should be happening) at every step. Medical errors are not unusual.
- Are you board-certified for this procedure?
- How many of these procedures have you done?
- What are your personal success rates for your patients’ long-term survival, incontinence, and erectile dysfunction?
- Will my age or health make this procedure too risky?
- What other tests should I have?
- How soon will my life be back to normal?
ACTIVE SURVEILLANCE (expectant management, watchful waiting)
PSA testing has made it possible to find cancers so small that many men do not need to be treated. Consider waiting if the cancer seems to be growing very slowly, you have a low Gleason score, and your life expectancy is 10 to 20 years. You will probably live as long, and you without risking any of the painful and permanent side effects that a procedure might cause.
PSA tests, DREs, and biopsies to monitor the cancer.
Exercise and better eating habits can slow tumor growth. And there will probably be plenty of time to be treated if it becomes necessary.
There may be tumors that were not found, or the cancer may begin to grow more rapidly. And it’s not easy to keep from worrying.
Survival rates are about the same for all of the procedures, but rates of the major side effects are not. Any procedure could damage nerves, organs, or muscles, allow cancer cells to escape, or lead to life-threatening complications.
You should do a lot of research before you choose a procedure. It is important to know what is happening (or should be happening) at every step. Medical errors are not unusual, especially with medications.
The following descriptions are not complete.
EXTERNAL RADIATION (external‑beam radiation, EBRT, RT)
Radiation damages cell DNA. Normal cells usually recover, cancer cells usually do not.
Patients go to a center once a day five times a week for six to eight weeks or twice a day for a shorter period.
Three‑dimensional conformal radiotherapy (3D-CRT)
X-rays are aimed from several angles to distribute radiation evenly and limit damage to other tissues and organs. The more-advanced types of X-ray equipment are:
Intensity-modulated radiotherapy (IMRT)
A computer adjusts hundreds of microbeams of variable intensities to match the shape of the prostate from every angle.
Image-guided IMRT (4D IGRT, IG‑IMRT)
This form of IMRT can track small movements such as those caused by breathing. The beams instantly adjust to changes in the shape or position of the prostate.
Hadron radiation (particle therapy)
The energy of proton, neutron, or ion beams can be focused to reach its strongest point inside tumors.
External radiation is usually painless. It can kill cancer cells at the edge of the prostate. Everyday life is only interrupted by the daily sessions.
Skin over the target area may become red and sensitive. Some diarrhea and urinary frequency is likely. You may feel tired. Few centers offer forms of hadron radiation, and it is much more expensive than X-ray therapy.
INTERNAL RADIATION (brachytherapy)
Permanent implants (seeds)
If the source of the radiation is inside the prostate, it can be more powerful, better-focused, and constant.
Tiny metal cylinders containing radioactive material are inserted at precise locations. Radiation weakens over three to six months, depending on the material.
Fast and relatively painless. Seeds can be placed outside the prostate to kill cancer cells that might have escaped. Everyday life can soon be resumed.
Urinary urgency and diarrhea occur when the body starts to react to the radiation. Misplaced or stray seeds can cause serious damage.
Temporary implants (high‑dose radiation, HDR)
Tumors that receive very high doses of radiation at the start of the treatment have less chance of recovering.
Highly radioactive materials are inserted in the prostate through temporary tubes for brief periods over several days. This is followed by a complete course of external-beam radiation.
Tumors receive higher doses of radiation than otherwise possible. Everyday life is only interrupted by the hospital stay and daily sessions of external-beam radiation.
Patients remain in a hospital bed during the first stage. Some diarrhea is likely. Patients may feel tired.
If the prostate comes out, so does the cancer.
The prostate is removed and the urethra is sewn back to the bladder. The types of prostatectomies are:
Retropubic A vertical incision about 4 inches (10 cm) long is made in the center of the lower abdomen.
Perineal A semi-circular incision is made behind the testicles.
Laparoscopic Several small incisions are made in the abdomen, through which miniature instruments and a tiny 2D video camera are inserted. They are controlled by a surgeon watching a television screen.
Robotic-assisted laparoscopic A form of laparoscopy in which the surgeon uses a computer to control the instruments and a 3D video camera.
The prostate is immediately examined to see if there are positive margins (indications that cancer cells reached the edge of the prostate). If they did, measures can be taken to kill them. Patients feel relieved because the prostate is no longer there.
Infections are common. Blood clots may occur in legs or lungs. Hernias may develop later on. A catheter must be worn for a week or more.
Note: Some procedures for treating BPH (non-cancerous tumors of the prostate) are sometimes called prostatectomies.
FREEZING (cryotherapy, cryosurgery, cryo)
Freezing kills cells.
An extremely cold liquid or gas is sent through very thin hollow needles to create tiny balls of ice in the tumors.
It is fast, relatively painless, and comparatively inexpensive. Everyday life can soon be resumed.
Normal cells do not recover. Dead tissue may block the urethra. A catheter must be worn for about a week.
HEATING (high-intensity focused ultrasound,
Premise Extreme heat kills cells.
High-energy ultrasonic waves are focused on tumors.
The heat only affects the tumors. Fast and relatively painless. Everyday life can soon be resumed.
Heat causes the prostate to swell, which may shift the tumors. Dead tissue may block the urethra. A catheter must be worn for about a week.
Focused ultrasound is only available in some countries. In 2015 the FDA approved it for the United States.
Following the procedure, you should have a course of external radiation or hormonal therapy (HT) to kill any cancer cells that might have escaped (adjuvant therapy).
If your prostate was very large or there were tumors near the edge, you might have had hormonal therapy before the procedure (neoadjuvant therapy) to shrink the prostate and tumors. HT must be carefully monitored because it may produce dangerous side effects.
Plan to remain nearby in case there are complications soon after the procedure. You will have to see your specialist a few times in the next few months for checkups.
If the cancer did not escape and there are no lasting side effects, you have a very good chance of leading a normal life. Continue to exercise, eat well, and have regular exams.
How successful your treatment is depends on your age, stage, general health, the type of procedure, your specialist’s skill, and a certain amount of luck.
Urinary problems may occur after a procedure and continue for a few weeks or longer. This may be permanent if organs, nerves, or muscles have been damaged, but there are ways to reduce or manage these problems.
Erectile dysfunction (ED, impotence)
Few men can have an erection right after a procedure. And if the nerves that control erections were damaged or removed, impotence may be a permanent condition. However, drugs and other solutions may still make it possible to have sex.
The longer you are cancer-free (in remission), the more likely it is the cancer will not return. If it does, there are salvage therapies that may be able to stop it.
A recurrence of the cancer is usually detected by a rapid rise in PSA (biochemical failure). But PSA levels can go up and down in the months after a procedure, so a rise may only be temporary.
Worrying about recurrence only makes it harder to enjoy the good things in your life.
If cancer spreads through the body (metastasizes), there are no treatments that can stop it, only ways to reduce pain and extend life. But if there are no more than five bone lesions (it is oligometastatic), aggressive treatment may produce significantly longer survival times.
hormone blockade, HT)
Blocking production of testosterone slows tumor growth.
Drugs or, in some cases, castration (orchiectomy).
When tumors no longer require testosterone, growth can be slowed by stopping the drugs.
Side effects may include hot flashes, anemia, abdominal pain, and liver failure. Tumors will eventually be able to grow with or without testosterone.
(radiation therapy, RT)
Relieves pain by reducing tumors that press against nerves and bones.
External radiation or injections of radioisotopes that migrate to tumors.
Bones are less likely to break. Patients feel better and may live longer.
Disadvantages Side effects may include lowered immunity, fatigue, and skin reactions.
Certain drugs can target and kill rapidly dividing cells, slowing the spread of the cancer and relieving some symptoms.
Drugs are delivered directly into the bloodstream (intravenously) during a hospital visit or using liquids, pills, or patient-operated devices.
Patients may live a bit longer. (Some extremely expensive drugs may extend life by a few more months.)
It is not effective for very long. Strong side effects may occur, including reduced immunity, anemia, memory loss, vomiting, and nerve and kidney damage. Different drugs have different side effects.
COMPLEMENTARY AND ALTERNATIVE THERAPIES
Complementary therapies do not replace medical treatments, they supplement them. Some, like massage or meditation, will not compromise your treatment, but others, such as herbs or dietary supplements, might. Check with your doctor first.
Alternative therapies have no scientific basis. They are also very expensive, may interfere with your treatment, raise unrealistic hopes, and don’t work.
If you have advanced cancer, consider taking part in a clinical trial of a potential cure. It is not likely to save your life, but what is learned might help save many lives in the future.
Finding Reliable Medical Information http://www.hypertext.org/ENGLISH/INFO.html
US Too support groups www.ustoo.org/
US Too international support groups http://www.ustoo.org/Chapter_NearYou.asp
Man to Man support groups http://goo.gl/ylnugA
Australian support groups http://www.prostate.org.au/support/
British support groups http://www.patient.co.uk/selfhelp.asp
Canadian support groups http://www.prostatecancer.ca
New Zealand support groups http://prostate.org.nz
Cancer support in more countries http://goo.gl/Jhv7f5
Prostate Problems E-Patient Group http://www2.acor.org/listservs/join/115
NCI’s Cancer Information Service http://www.cancer.gov/aboutnci/cis/page1
Cancer Financial Assistance Coalition
Consumer Health Resources http://www.citizen.org/hrg/links/index.cfm
American Cancer Society http://www.cancer.org/cancer/prostatecancer/index
Prostate Cancer Research Institute newsletters http://pcri.org/insights-newsletter/
Hormonal therapy http://goo.gl/iuzw1
About erectile dysfunction (ED) http://goo.gl/X0wMS
About urinary incontinence
ClinicalTrials.gov database https://www.clinicaltrials.gov/
Cancer Financial Assistance Coalition http://goo.gl/Es9mx9
Consumer Health Resources http://www.citizen.org/hrg/links/index.cfm
Getting your medical records http://patients.about.com/od/yourmedicalrecords/a/getmedrecords.htm
Health Insurance in the U.S.
A Primer on Prostate Cancer, Stephen B. Strum M. D. and Donna Pogliano
The Dattoli Challenge, Michael Dattoli M. D. and Jennifer Cash ARNP
Man to Man: Surviving Prostate Cancer, Michael Korda (patient)
The Hypertext Guide to Prostate Cancer is one of several “high quality and informative sites” that address specific types of cancer: Cancer information resources: digital and online sources (PMID: 11955682).
Disclaimer: This overview is only intended for educational purposes. It is not a substitute for informed medical advice from a physician.
Permission to reproduce: Individuals may print copies for personal use but may not change it, publish it, upload it to a website, or sell it without the written permission of the author. Support groups may make copies for their members. http://www.hypertext.org/ENGLISH/PERM.html.
Permission for support groups: www.hypertext.org/ENGLISH/perm.html
Copyright © by William Dyckes 1997-2016 firstname.lastname@example.org